SnapShot: Reactive Oxygen Intermediates (ROI)

SnapShot: Reactive Oxygen Intermediates (ROI)

Response of Mycobacterium tuberculosis to reactive oxygen and nitrogen intermediates.

BACKGROUND Mycobacterium tuberculosis is a significant human pathogen capable of replicating in mononuclear phagocytic cells. Exposure to reactive oxygen and nitrogen intermediates is likely to represent an important aspect of the life cycle of this organism. The response of M. tuberculosis to these agents may be of significance for its survival in the host. MATERIALS AND METHODS Patterns of ...

Modulation of alveolar fluid clearance by reactive oxygen-nitrogen intermediates.

IN THIS ISSUE of AJP-Lung, Kaestle et al. (28) report that an increase in left atrial pressure in isolated perfused lungs induces a Ca -dependent increase of endothelial nitric oxide (NO) production, which decreases reabsorption of fluid across the alveolar epithelium, resulting in pulmonary edema. Furthermore, they report that in chronic heart failure, NO production by endothelial cells is imp...

Reactive nitrogen and oxygen intermediates in patients with cutaneous leishmaniasis.

The metabolisms of reactive nitrogen and oxygen intermediates (RNI and ROI) in patients with cutaneous leishmaniasis (CL) were investigated and compared with those of healthy subjects. To determine RNI metabolism, nitrite plus nitrate concentrations were measured spectrophotometrically. Nitrite concentration in plasma was determined directly by the Griess method. Nitrate levels in plasma were m...

CD40 ligand influences platelet release of reactive oxygen intermediates.

OBJECTIVE Soluble CD40 ligand (sCD40L) has been recently implicated in the pathogenesis of atherosclerosis. Elevated levels of sCD40L in acute coronary syndrome patients suggests enhanced platelet function; however, the exact mechanism by which this occurs is unknown. In this study, we examined the effect of sCD40L on platelet function and reactive oxygen and nitrogen species (RONS) generation....